Raynaud's phenomenon should be distinguished from acrocyanosis, a condition in which there is persistent bluish discoloration of the hands or feet. Like Raynaud's phenomenon, cyanotic discoloration intensifies during cold exposure, and rubor may appear with rewarming.

Acrocyanosis affects both men and women, and the age at onset is usually between 20 and 45 years. The prognosis of patients with idiopathic acrocyanosis is good, and loss of digital tissue is uncommon. Patients should avoid cold exposure and dress warmly. Pharmacologic intervention usually is not necessary. Alpha-adrenergic blocking agents and calcium channel blockers may be effective in some patients with acrocyanosis.